Preclinical Foundation for Normothermic Machine Liver Preservation
نویسندگان
چکیده
منابع مشابه
Normothermic Machine Preservation of the Liver: State of the Art
Purpose of Review This review aims to introduce the concept of normothermic machine perfusion (NMP) and its role in liver transplantation. By discussing results from recent clinical studies and highlighting the potential opportunities provided by this technology, we aim to provide a greater insight into NMP and the role it can play to enhance liver transplantation. Recent Findings NMP has rec...
متن کاملLiver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial.
The number of donor organs suitable for liver transplantation is restricted by cold preservation and ischemia-reperfusion injury. We present the first patients transplanted using a normothermic machine perfusion (NMP) device that transports and stores an organ in a fully functioning state at 37°C. In this Phase 1 trial, organs were retrieved using standard techniques, attached to the perfusion ...
متن کاملNormothermic kidney preservation.
PURPOSE OF REVIEW Kidneys from marginal or donation after cardiac death (DCD) donors are particularly susceptible to injury during hypothermic preservation and may benefit from alternative methods of preservation. Normothermic preservation can be adapted to improve the quality of kidneys for transplantation by a variety of techniques. RECENT FINDINGS Extracorporeal membrane support to maintai...
متن کاملSuccessful transplantation of porcine liver grafts following 48-hour normothermic preservation
Current cold storage organ preservation technique fails to preserve marginal donor grafts sufficiently. Evidence from large animal experiments suggests superiority of normothermic machine preservation of liver allografts. Long-term organ preservation using normothermic perfusion might not only allow organ viability assessment before transplantation, but also provide the means for further organ ...
متن کاملHypothermic Machine Preservation of the Liver: State of the Art
Purpose of Review In this review, we highlight which livers may benefit from additional treatment before implantation and describe the concept of hypothermic machine liver perfusion. Furthermore, we explain why cold oxygenated perfusion concepts could potentially lead to a breakthrough in this challenging field of transplantation. Accordingly, we summarize recent clinical applications of differ...
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ژورنال
عنوان ژورنال: Current Transplantation Reports
سال: 2015
ISSN: 2196-3029
DOI: 10.1007/s40472-014-0037-2